Transformational cell therapies for patients with serious diseases.


Kyslecel™ Personalized Cell Therapy

Koligo Therapeutics, Inc.  is excited to announce it has entered into a merger agreement with Orgenesis, Inc. – read more


Permanent relief from the pain of chronic pancreatitis and durable glycemic control is possible with Kyslecel (autologous pancreatic islets)

When dietary control, pain medication, and endoscopic procedures fail to provide relief for the unrelenting pain caused by chronic pancreatitis, surgery may be a solution. For a growing number of patients, pancreatectomy (removal of the pancreas) with islet auto-transplantation (TP-IAT) can provide significant pain relief with long-term glycemic control.

Kyslecel is made from your own pancreatic islets – the cells that produce insulin in your pancreas. Your surgeon removes the diseased pancreas (source of pain and inflammation), sends it to Koligo, and we preserve your islets to make Kyslecel. Kyslecel is then infused into your liver where the islets are expected to function and produce the insulin needed to regulate your blood sugar. TP-IAT with Kyslecel is available for children and adults in the United States. It is covered by all major commercial health insurers (including Medicare supplement plans), many state Medicaid carriers, and Veteran’s Affairs.

Most patients with chronic pancreatitis (nearly 80%) will eventually develop diabetes as the disease progresses and the pancreas degenerates. TP-IAT with Kyslecel may be considered earlier in the course of the disease to preserve islet function before becoming diabetic.

Not every patient who undergoes TP-IAT with Kyslecel will achieve blood sugar control and some patients may require life-long insulin therapy. All patients will require life-long enzyme replacement therapy. TP-IAT is a major surgery and carries significant risks. You should speak to your doctor about the potential benefits and risks associated with TP-IAT and Kyslecel.

How Kyslecel Works

Koligo personalized cell therapy for chronic pancreatitis. Because pain should not define your life.


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