Transformational cell therapies for patients with pancreatic disease

Koligo experts share latest thinking.

Relevant studies, outcomes and assessments.

SELECTED PUBLICATIONS AUTHORED BY KOLIGO TEAM

Cystic fibrosis-related diabetes is caused by islet loss and inflammation.

Hart NJ, Aramandla R, Poffenberger G, Fayolle C, Thames AH, Bautista A, Spigelman AF, Babon JAB, DeNicola ME, Dadi PK, Bush WS, Balamurugan AN, Brissova M, Dai C, Prasad N, Bottino R, Jacobson DA, Drumm ML, Kent SC, MacDonald PE, Powers AC. JCI Insight. 2018 Apr 19;3(8). pii: 98240. doi: 10.1172/jci.insight.98240. [Epub ahead of print] PMID: 29669939

Beneficial effect of recombinant rC1rC2 collagenases on human islet function: Efficacy of low-dose enzymes on pancreas digestion and yield.

Loganathan G, Subhashree V, Breite AG, Tucker WW, Narayanan S, Dhanasekaran M, Mokshagundam S, Green ML, Hughes MG, Williams SK, Dwulet FE, McCarthy RC, Balamurugan AN. Am J Transplant. 2018 Feb;18(2):478-485. doi: 10.1111/ajt.14542. Epub 2017 Dec 9. PMID: 29044985

Vasculogenic and angiogenic potential of adipose stromal vascular fraction cell populations in vitro.

Zakhari JS, Zabonick J, Gettler B, Williams SK. In Vitro Cell Dev Biol Anim. 2018 Jan;54(1):32-40. doi: 10.1007/s11626-017-0213-7. Epub 2017 Dec 1. PMID: 29197029

Adipose-derived cellular therapies in solid organ and vascularized-composite allotransplantation.

Stivers KB, Beare JE, Chilton PM, Williams SK., Kaufman CL, Hoying JB. Curr Opin Organ Transplant. 2017 Oct;22(5):490-498. doi: 10.1097/MOT.0000000000000452. Review. PMID: 28873074

Formation of Adipose Stromal Vascular Fraction Cell-Laden Spheroids Using a Three-Dimensional Bioprinter and Superhydrophobic Surfaces.

Gettler BC, Zakhari JS, Gandhi PS, Williams SK. Tissue Eng Part C Methods. 2017 Sep;23(9):516-524. doi: 10.1089/ten.TEC.2017.0056. Epub 2017 Aug 10. PMID: 28665236

Intra-islet endothelial cell and β-cell crosstalk: Implication for islet cell transplantation.

Narayanan S, Loganathan G, Dhanasekaran M, Tucker W, Patel A, Subhashree V, Mokshagundam S, Hughes MG, Williams SK, Balamurugan AN. World J Transplant. 2017 Apr 24;7(2):117-128. doi: 10.5500/wjt.v7.i2.117. Review. PMID: 28507914

First Report of Successful Total Pancreatectomy and Islet Autotransplant in Australia.

Geyer MC, Coates PT, Khurana S, Chen JW, Kay TW, Balamurugan AN, Couper JJ, Radford T, Drogemuller CJ, Loudovaris T, Pathi R, Wilks MJ, Couper RT. Pancreas. 2017 Mar;46(3):e18-e20. doi: 10.1097/MPA.0000000000000769. No abstract available. PMID: 28187110

National Institutes of Health-Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities.

Ricordi C, Goldstein JS, Balamurugan AN, Szot GL, Kin T, Liu C, Czarniecki CW, Barbaro B, Bridges ND, Cano J, Clarke WR, Eggerman TL, Hunsicker LG, Kaufman DB, Khan A, Lafontant DE, Linetsky E, Luo X, Markmann JF, Naji A, Korsgren O, Oberholzer J, Turgeon NA, Brandhorst D, Chen X, Friberg AS, Lei J, Wang LJ, Wilhelm JJ, Willits J, Zhang X, Hering BJ, Posselt AM, Stock PG, Shapiro AM, Chen X. Diabetes. 2016 Nov;65(11):3418-3428. Epub 2016 Jul 27. Erratum in: Diabetes. 2017 Sep;66(9):2531. PMID: 27465220

A Multicenter Study: North American Islet Donor Score in Donor Pancreas Selection for Human Islet Isolation for Transplantation.

Wang LJ, Kin T, O’Gorman D, Shapiro AMJ, Naziruddin B, Takita M, Levy MF, Posselt AM, Szot GL, Savari O, Barbaro B, McGarrigle J, Yeh CC, Oberholzer J, Lei J, Chen T, Lian M, Markmann JF, Alvarez A, Linetsky E, Ricordi C, Balamurugan AN, Loganathan G, Wilhelm JJ, Hering BJ, Bottino R, Trucco M, Liu C, Min Z, Li Y, Naji A, Fernandez LA, Ziemelis M, Danobeitia JS, Millis JM, Witkowski P. Cell Transplant. 2016;25(8):1515-1523. doi: 10.3727/096368916X691141. Epub 2016 Feb 26. PMID: 2692294

Identifying Effective Enzyme Activity Targets for Recombinant Class I and Class II Collagenase for Successful Human Islet Isolation.

Balamurugan AN, Green ML, Breite AG, Loganathan G, Wilhelm JJ, Tweed B, Vargova L, Lockridge A, Kuriti M, Hughes MG, Williams SK, Hering BJ, Dwulet FE, McCarthy RC. Transplant Direct. 2015 Dec 23;2(1):e54. doi: 10.1097/TXD.0000000000000563. eCollection 2016 Jan. PMID: 27500247

Islet Oxygen Consumption Rate (OCR) Dose Predicts Insulin Independence in Clinical Islet Autotransplantation.

Papas KK, Bellin MD, Sutherland DE, Suszynski TM, Kitzmann JP, Avgoustiniatos ES, Gruessner AC, Mueller KR, Beilman GJ, Balamurugan AN, Loganathan G, Colton CK, Koulmanda M, Weir GC, Wilhelm JJ, Qian D, Niland JC, Hering BJ. PLoS One. 2015 Aug 10;10(8):e0134428. doi: 10.1371/journal.pone.0134428. eCollection 2015. PMID: 26258815

Positive sterility cultures of transplant solutions during pancreatic islet autotransplantation are associated infrequently with clinical infection.

Colling KP, Blondet JJ, Balamurugan AN, Wilhelm JJ, Dunn T, Pruett TL, Sutherland DE, Chinnakotla S, Bellin M, Beilman GJ. Surg Infect (Larchmt). 2015 Apr;16(2):115-23. doi: 10.1089/sur.2013.224. Epub 2015 Feb 10. PMID: 25668050

Assessment of β-cell mass and α- and β-cell survival and function by arginine stimulation in human autologous islet recipients.

Robertson RP, Bogachus LD, Oseid E, Parazzoli S, Patti ME, Rickels MR, Schuetz C, Dunn T, Pruett T, Balamurugan AN, Sutherland DE, Beilman G, Bellin MD. Diabetes. 2015 Feb;64(2):565-72. doi: 10.2337/db14-0690. Epub 2014 Sep 3. PMID: 25187365

Islet product characteristics and factors related to successful human islet transplantation from the Collaborative Islet Transplant Registry (CITR) 1999-2010.

Balamurugan AN, Naziruddin B, Lockridge A, Tiwari M, Loganathan G, Takita M, Matsumoto S, Papas K, Trieger M, Rainis H, Kin T, Kay TW, Wease S, Messinger S, Ricordi C, Alejandro R, Markmann J, Kerr-Conti J, Rickels MR, Liu C, Zhang X, Witkowski P, Posselt A, Maffi P, Secchi A, Berney T, O’Connell PJ, Hering BJ, Barton FB. Am J Transplant. 2014 Nov;14(11):2595-606. doi: 10.1111/ajt.12872. Epub 2014 Oct 2. PMID: 2527815

Islet preparation purity is overestimated, and less pure fractions have lower post-culture viability before clinical allotransplantation.

Kitzmann JP, Karatzas T, Mueller KR, Avgoustiniatos ES, Gruessner AC, Balamurugan AN, Bellin MD, Hering BJ, Papas KK. Transplant Proc. 2014 Jul-Aug;46(6):1953-5. doi: 10.1016/j.transproceed.2014.06.011. PMID: 25131080

Long-term outcomes of total pancreatectomy and islet auto transplantation for hereditary/genetic pancreatitis.

Chinnakotla S, Radosevich DM, Dunn TB, Bellin MD, Freeman ML, Schwarzenberg SJ, Balamurugan AN, Wilhelm J, Bland B, Vickers SM, Beilman GJ, Sutherland DE, Pruett TL. J Am Coll Surg. 2014 Apr;218(4):530-43. doi: 10.1016/j.jamcollsurg.2013.12.037. Epub 2014 Jan 10. PMID: 24655839

Total pancreatectomy and islet autotransplantation in children for chronic pancreatitis: indication, surgical techniques, postoperative management, and long-term outcomes.

Chinnakotla S, Bellin MD, Schwarzenberg SJ, Radosevich DM, Cook M, Dunn TB, Beilman GJ, Freeman ML, Balamurugan AN, Wilhelm J, Bland B, Jimenez-Vega JM, Hering BJ, Vickers SM, Pruett TL, Sutherland DE. Ann Surg. 2014 Jul;260(1):56-64. doi: 10.1097/SLA.0000000000000569. PMID: 24509206

Encapsulation of adipose stromal vascular fraction cells in alginate hydrogel spheroids using a direct-write three-dimensional printing system.

Williams SK, Touroo JS, Church KH, Hoying JB. Biores Open Access. 2013 Dec 1;2(6):448-54. doi: 10.1089/biores.2013.0046. PMID: 24380055

Kyslecel personalized cell therapy for chronic pancreatitis. Because pain should not define your life.