Transformational cell therapies for patients with pancreatic disease

Our Koligo pipeline of therapies is rich and robust.

We are looking years ahead to continue to advance a cure for chronic pancreatitis and type 1 diabetes.

Koligo’s Technology Platform

Koligo’s R&D is focused on technologies that would greatly improve patient access to cell/tissue transplant and improve the safety and efficacy of cell/tissue transplant products:

  • Faster re-vascularization/inosculation of cell/tissue transplant to improve engraftment
  • Host tolerance of the graft while minimizing need for immune suppressive drugs
  • Better site of transplant administration for islets – i.e. not in the liver
  • Scaffolding or other structure to keep cell/tissue in place in vivo

Culture of stromal vascular stem cells (SVF) and/or micro-vascular fragments (MVF) obtained from the recipient patient induces vascularization of the cells for transplant

  • Significant functional vessel growth observed after about 10 days (image A)
  • Improved function (better engraftment) observed in animal studiesChimerize

Preliminary data indicate that culture of allogeneic islets with recipient SVF may reduce potential for host rejection of the transplant (“chimerize”)

Collagenase spheroids containing SVF/MVF and islets are scalable in production and provide a bio-degradable scaffold to deliver islets and allow for engraftment subcutaneously.

  • 3D structure in which cells are suspended allow for better vascularization
  • Allows for cells to be implanted in an organ-like structure, rather than be infused where cells could be lost

SPHEROIDS BEING 3D BIO-PRINTED

Speheriods being 3D bio-printed

BIO-PRINTED 3D SPHEROID CONTAINING PANCREATIC ISLETS

Bioprinted 3D spheroid containing pancreatic islets

SVF-ISLET-SPHEROIDS FUNCTION NORMALLY IN VITRO

Glucose Stimulated Insulin Release

SVF-ISLET SPHEROIDS: NONCLINICAL PROOF OF CONCEPT

Reversal of diabetes

Kyslecel personalized cell therapy for chronic pancreatitis. Because pain should not define your life.