“Chronic pancreatitis (CP) is inflammation of the pancreas that does not heal or improve—it gets worse over time and leads to permanent damage. Chronic pancreatitis eventually impairs a patient’s ability to digest food and make pancreatic hormones. Chronic pancreatitis often develops in patients between the ages of 30 and 40, and is more common in men than women.” ––National Pancreas Foundation
CP can lead to a number of secondary complications, some of which are serious if not treated appropriately: chronic debilitating pain, diabetes mellitus, malnutrition, metabolic bone disease, and pancreatic cancer.
The only cure for CP is total pancreatectomy (TP). However, TP raises other risks including diabetes mellitus, exocrine insufficiency, and the risks associated with a major surgery. Islet auto transplant (IAT) after TP can mitigate some of these risks. Koligo’s experience with TP-IAT demonstrates that increasing numbers of patients will benefit from TP-IAT and achieve long-term pain relief from CP, increased quality of life, and a good chance for insulin independence.
There are a number of excellent resources to learn more about chronic pancreatitis and related complications, the risks and benefits of various treatments:
“Type 1 diabetes, once known as juvenile diabetes or insulin-dependent diabetes, is a chronic condition in which the pancreas produces little or no insulin. Insulin is a hormone needed to allow sugar (glucose) to enter cells to produce energy. Different factors, including genetics and some viruses, may contribute to type 1 diabetes. Although type 1 diabetes usually appears during childhood or adolescence, it can develop in adults. Despite active research, type 1 diabetes has no cure. Treatment focuses on managing blood sugar levels with insulin, diet and lifestyle to prevent complications” – Mayo Clinic
Over time, type 1 diabetes can lead to a number of secondary complications, some of which are serious if not treated appropriately: heart and blood vessel disease, nerve damage, kidney damage, eye damage and blindness, foot damage, and skin and mouth damage.
There is no cure for type 1 diabetes. There are some experimental treatments being tested in clinical trials that may prevent further destruction of islets in type 1 diabetic patients. These can be found at www.clinicaltrials.org.
Allogeneic islet transplant (“Allo-islet” transplant) uses pancreatic islets that have been obtained from deceased organ donors for infusion into the liver of a type 1 diabetic patient. Allo-islet transplant has demonstrated promising results for type 1 diabetics who suffer from severe hypoglycemic unawareness in clinical trials funded by the U.S. National Institutes of Health. Several institutions are continuing clinical studies of islet transplant.
Koligo’s approach to allo-islet transplant (Stylecel-L) intends to build from the successful clinical data in the NIH trials by developing a product that is scalable in production and can be transplanted under the skin (not infused in the liver).
There are a number of excellent resources to learn more about type 1 diabetes and related complications, the risks and benefits of various treatments: